Authors: Forno, G., Zitko, P., Lillo, P., Thumala, D., Henriquez, F., Garcia, A.M., Cerda, M., Ibañez, A., Martinez-Pernia, D., Mioshi, E., Homberger, M., Schmitter-Edgecombe, M. & Slachevsky, A.​

Abstract: INTROCUTION
The relationship between functional ability and neuropsychiatric or cognitive factors in older adults with cognitive complaints (CCs) remains unexplored in Latin America.

METHODS
Two hundred ninety community-dwelling older adults with CCs were recruited. Multiple regression analyzed the association between activities of daily living (ADLs) and neuropsychiatric and cognitive factors. Variance proportion in ADLs were further explored.

RESULTS
Apathy was associated with reduced functional ability (Technology-Activities of Daily Living Questionnaire [T-ADLQ] global score [β = −0.42, 95% confidence interval [CI] [−0.57, −0.28]). Depression was linked to impaired advanced ADLs (β = 0.94, 95% CI [0.09, 1.79]) and basic ADLs (β = 0.22, 95% CI [0.03, 0.42]). Naming and speeded processing were significantly associated with global ADLs (β = −0.55, 95% CI [−0.99, −0.12]; β = 0.26, 95% CI [0.04, 0.48], respectively) and distinct ADLs sub-scores.

DISCUSSION
Neuropsychiatric and cognitive factors affect ADLs based on their complexity. These results call for targeted interventions supporting independence in Latin American older adults.