PROYECTO














Proyecto
Este proyecto impulsa un Consorcio respaldado por múltiples socios cuyo objetivo es extender la investigación sobre la demencia en América Latina y el Caribe (ALC). ReDLat pretende combinar datos genómicos, de neuroimagen y conductuales (clínicos, cognitivos, socioeconómicos) para mejorar la caracterización de la demencia e identificar nuevas vías para tratar la neurodegeneración en diversas poblaciones. Este proyecto de 5 años de duración representa una oportunidad sin precedentes para fomentar la sinergia regional y la investigación multidisciplinar con el fin de promover la armonización de estrategias globales para tratar y, en última instancia, prevenir la demencia en poblaciones diversas y desatendidas de todo el mundo. Desarrollaremos un enfoque innovador, armonizado y transregional sobre dos de sus trastornos neurodegenerativos más prevalentes: la enfermedad de Alzheimer (EA) y la demencia frontotemporal (DFT).
Combinamos financiación del National Institute on Aging (“US-South American initiative for genetic-neural-behavioral interactions in human neurodegenerative research”, R01 AG057234) con apoyo adicional. El proyecto R01 proporciona una plataforma básica anclada en Argentina, Brasil, Colombia y Perú, que se complementa con la experiencia en investigación clínica del Memory and Aging Center de la Universidad de California, San Francisco (UCSF), la experiencia en genómica de la Universidad de California en Santa Bárbara y la infraestructura y experiencia en bioinformática de HudsonAlpha. Posteriormente, otros países (México, Chile y otros del consorcio LAC-CD) se unieron al proyecto con el apoyo de la Alzheimer's Association y la Rainwater Charitable Foundation. Los proyectos satélite están ampliando la iniciativa inicial de ReDLat para incluir evaluaciones familiares (Alector, Bluefield), registros de EEG (Takeda), análisis del habla natural (NIH/NIA) y experiencias de aprendizaje (BrainLat, GBHI).
Objetivo 1: Establecer las contribuciones genéticas a la EA y la FTD en diversas cohortes de
America Latina y CaribeEste proyecto impulsa un Consorcio respaldado por múltiples socios cuyo objetivo es extender la investigación sobre la demencia en América Latina y el Caribe (ALC). ReDLat pretende combinar datos genómicos, de neuroimagen y conductuales (clínicos, cognitivos, socioeconómicos) para mejorar la caracterización de la demencia e identificar nuevas vías para tratar la neurodegeneración en diversas poblaciones. Este proyecto de 5 años de duración representa una oportunidad sin precedentes para fomentar la sinergia regional y la investigación multidisciplinar con el fin de promover la armonización de estrategias globales para tratar y, en última instancia, prevenir la demencia en poblaciones diversas y desatendidas de todo el mundo. Desarrollaremos un enfoque innovador, armonizado y transregional sobre dos de sus trastornos
neurodegenerativos más prevalentes: la enfermedad de Alzheimer (EA) y la demencia frontotemporal (DFT).
Combinamos financiación del National Institute on Aging (“US-South American initiative for genetic-neural-behavioral interactions in human neurodegenerative research”, R01 AG057234) con apoyo adicional. El proyecto R01 proporciona una plataforma básica anclada en Argentina, Brasil, Colombia y Perú, que se complementa con la experiencia en investigación clínica del Memory and Aging Center de la Universidad de California, San Francisco (UCSF), la experiencia en genómica de la Universidad de California en Santa Bárbara y la infraestructura y experiencia en bioinformática de HudsonAlpha. Posteriormente, otros países (México, Chile y otros del consorcio LAC-CD) se unieron al proyecto con el apoyo de la Alzheimer’s Association y la Rainwater Charitable Foundation. Los proyectos satélite están ampliando la iniciativa inicial de ReDLat para incluir evaluaciones familiares (Alector, Bluefield), registros de EEG (Takeda), análisis del habla natural (NIH/NIA) y experiencias de aprendizaje (BrainLat, GBHI).
Esta propuesta se extiende a colaboradores en México y Chile. También evaluaremos nuevas familias a través del Consorcio Latinoamericano y del Caribe sobre Demencia (LAC-CD). Además de la estrategia del proyecto R01, basada en pacientes con cuadros familiares y esporádicos sometidos a pruebas de riesgos genéticos, también apoyará el reclutamiento de familias con EA y FTD con una presentación autosómica dominante provenientes de la plataforma LAC-CD. Esta plataforma facilitará numerosos proyectos de investigación de grupos adicionales; aprovechará la experiencia regional en envejecimiento y demencia para establecer un consorcio multidisciplinario y colaborativo de clínicos e investigadores internacionales diversos; y promoverá el desarrollo de la próxima generación de investigadores en envejecimiento y demencia en LAC. En este marco ampliado, primero examinaremos a todos los pacientes en busca de genes conocidos de EA/FTD/ALS y luego, para aquellos que den negativo en la prueba de causas genéticas conocidas de la enfermedad, realizaremos la secuenciación del genoma completo para el descubrimiento de
genes. Aprovechando los esfuerzos del R01 y ampliando el alcance del proyecto para incluir a México, Chile y nuevas familias de LAC-CD, estableceremos una red de familias y médicos/investigadores de EA y FTD, permitiendo la investigación a gran escala para identificar nuevas contribuciones genéticas y SES a la EA y FTD en diversas poblaciones. Al establecer este marco de colaboración, que capitaliza poblaciones regionales únicas, nuestra propuesta puede consolidar una plataforma basada en LAC para la futura investigación y evaluación traslacional. Nuestro objetivo a largo plazo es identificar los factores genéticos y socioeconómicos únicos que impulsan la presentación de la EA y la FTD en ALC en relación con los EE.UU., incluidos los factores de riesgo, los perfiles cognitivos y las imágenes cerebrales. Con este fin, estableceremos una cohorte de primera clase anclada en seis LAC (Argentina, Chile, Colombia, Brasil, México y Perú), comparada con muestras de EE.UU. (con un total de > 4200 participantes, incluyendo 2100 controles, 1050 pacientes con EA y 1050 pacientes con FTD), dirigida por líderes de renombre mundial en la investigación de la demencia. Combinaremos evaluaciones clínicas estandarizadas con técnicas analíticas innovadoras para tener en cuenta la heterogeneidad en estas poblaciones tan diversas. Mediante la combinación de medidas estandarizadas genéticas, de neuroimagen y conductuales (cognitivas y SES), probaremos la hipótesis subyacente de que existen factores de riesgo únicos para la EA y la FTD en ALC (por ejemplo, factores de riesgo genéticos enriquecidos en poblaciones de ALC; vulnerabilidad cognitiva y neural subyacente debida a SES) en comparación con las poblaciones estadounidenses. Nuestro plan para reclutar un gran número de controles y pacientes a través de estas diversas poblaciones proporcionará excelentes oportunidades para identificar nuevos riesgos genéticos y SES para AD y FTD. Además, las estrategias de aprendizaje automático que hemos desarrollado para reducir el impacto de la heterogeneidad de fondo nos permitirán refinar la precisión de nuestros estudios de asociación. En este contexto, perseguiremos los siguientes objetivos específicos:
Objetivo 1: Establecer las contribuciones genéticas a la EA y la FTD en diversas cohortes de America Latina y Caribe(estudio de Nivel 1, con un tamaño de muestra mayor que el Nivel 2). Al elucidar la subestructura genética y las contribuciones familiares a la EA y la FTD en ALC en comparación con los EE.UU., podremos identificar poblaciones adecuadas para la replicación de nuestros hallazgos genéticos. Al reunir esta gran cohorte, también estaremos bien posicionados para establecer un puntaje de riesgo poligénico específico para ALC para predecir el riesgo de EA y DFT en muestras futuras.
1. Identificar la prevalencia de factores de riesgo autosómicos dominantes y variantes raras de EA y FTD en determinados genes.
Nuestra hipótesis es que, en relación con los EE. UU., ALC tiene una mayor frecuencia de formas familiares de EA y FTD. El descubrimiento de nuevas familias con múltiples individuos afectados hará avanzar los esfuerzos para tratar la EA y la FTD en pacientes con mutaciones poco frecuentes (PS1, APP, MAPT, GRN y C9orf72).
2. Realizar estudios exploratorios de asociación de genoma completo en subgrupos de ALC.
Nuestra hipótesis es que, en comparación con los pacientes de EE. UU., los países de América Latina y el Caribe están más expuestos a nuevos riesgos en los genes del metabolismo de los lípidos (EA) y la función lisosomal (DFT).
3. Probar si las puntuaciones de riesgo poligénico desarrolladas en poblaciones europeas de EA y FTD resultan válidas en América Latina y el Caribe.
Nuestra hipótesis es que las PRS funcionarán mejor para discriminar a los pacientes de los controles en la sub-población predominantemente europea (EE.UU. y, en menor medida, Argentina, Chile) que en las cohortes mixtas de mayoría africana e indígena (Perú, Brasil, Colombia, México).
Objetivo 2: dilucidar el impacto de la situación socioeconómica en las características clínicas, cognitivas y de imágenes cerebrales en Latinoamérica y Estados Unidos. (Estudio de nivel 2: evaluación cognitiva y de imágenes exhaustiva en un subconjunto del nivel 1). Para comparar pacientes entre regiones, necesitamos establecer medidas neurocognitivas estandarizadas y entender cómo los determinantes socioeconómicos impactan en las manifestaciones de demencia en America Latina y Caribe.
1. Evaluar cómo el nivel socioeconómico modera la relación entre la edad de inicio y la gravedad de la enfermedad en la EA y la FTD.
Nuestra hipótesis es que la EA y la DFT aparecerán a una edad más temprana en los pacientes de nivel socioeconómico bajo frente a los de nivel socioeconómico alto (dicotomizados), y que las medidas de gravedad de la enfermedad, incluido el rendimiento cognitivo y la neuroimagen multimodal, serán peores en el grupo de nivel socioeconómico bajo incluso después de corregir por edad.
2. Evaluar el impacto diferencial del nivel socioeconómico en los déficits clínicos, cognitivos y de imágenes cerebrales en las muestras de Latinoamérica frente a las de Estados Unidos.
Nuestra hipótesis es que la diferencia en las calificaciones de gravedad de la enfermedad, la
cognición y la neuroimagen multimodal que reflejan las disparidades de SES bajo frente a alto será mayor en los pacientes de América Latina y el Caribe en comparación con los pacientes de Estados Unidos.
Objetivo 3: Determinar si el riesgo genético y el nivel socioeconómico permiten discriminar mejor entre pacientes latinoamericanos y estadounidenses en comparación con otras variables cognitivas, de neuroimagen y clínicas (niveles 1 y 2). Hasta la fecha, ningún estudio ha intentado establecer qué predictores potenciales resultan más sensibles para discriminar entre pacientes de ALC y EE.UU. En particular, aunque el riesgo genético y el nivel socioeconómico (Objetivos 1 y 2) tienen el potencial de diferenciar sólidamente entre dichas muestras, ningún estudio ha explorado su papel, y mucho menos en comparación con otros factores multimodales. Para abordar esta
cuestión, aplicaremos un análisis de aprendizaje automático basado en datos para determinar los factores principales que mejor discriminan a los pacientes de ALC de los de EE. UU. Las medidas multimodales de los controles de cada país se utilizarán para la normalización específica de la población de los datos de los pacientes. Nuestra hipótesis es que las características principales que mejor discriminan a los pacientes de ALC de los de EE.UU. estarán relacionadas con el NSE y el riesgo genético (por ejemplo, puntuaciones de riesgo poligénico estandarizadas) en comparación con otras variables (medidas clínicas, cognitivas y de imagen).
El resultado esperado de este estudio es una gran cohorte latinoamericana de pacientes y controles armonizados y bien caracterizados de EA y FTD (Fig 1). Los impactos positivos de este trabajo incluyen una mejor comprensión de las contribuciones genéticas y socioeconómicas a las manifestaciones neurocognitivas de la demencia y la identificación de nuevos objetivos para la reducción del riesgo y la prevención de la enfermedad en América Latina y el Caribe. Nuestro amplio estudio multimodal y transversal permitirá la evaluación clínica de grupos de pacientes poco estudiados, ampliará y armonizará los conjuntos de datos existentes, impulsará el desarrollo
de nuevas medidas e informará el trabajo futuro sobre el valor clínico de los perfiles multimodales combinados para predecir la presentación y progresión de la enfermedad en estudios longitudinales de diversas poblaciones.
Marilu Gorno Tempini
BIO
Dr. Maria Luisa Gorno Tempini is a behavioral neurologist and holds the Charles Schwab Endowed Professorship in Dyslexia and Neurodevelopment. She currently directs the Language Neurobiology Laboratory at the UCSF Memory and Aging Center and co-directs the UCSF Dyslexia Center. She obtained her medical degree and clinical neurology specialty training in Italy and has a doctorate in the neuroimaging of language from University College London.
Her clinical work concentrates on behavioral neurology across the lifespan, and her research investigates the neural basis of higher cognitive functions such as language and memory. Dr. Gorno Tempini has applied her expertise in cognitive neurology to neurodegenerative diseases, particularly primary progressive aphasia (PPA) and frontotemporal dementia (FTD), and to language-based learning differences, such as dyslexia. In 2011, Dr. Gorno Tempini’s NIH-funded research resulted in new diagnostic criteria for PPA and its variants.
In 2014, Dr. Gorno Tempini co-founded the UCSF Dyslexia Center, which aims to classify dyslexia into behavioral phenotypes defined by patterns of neuropsychological strengths and weaknesses. These efforts will lead to more targeted assessments and treatments amongst clinical and educational systems. The UCSF Dyslexia Center brings together neurologists, psychiatrists, biomedical engineers, radiologists, neuropsychologists, speech-language pathologists and research coordinators to discover structural and functional differences in the brains of children and older adults with dyslexia.
Dr. Gorno Tempini leads many projects at UCSF and is funded by the NIH and various philanthropic sources. She is particularly dedicated to mentoring and was awarded an NIH K24 grant to mentor interdisciplinary researchers in the field of clinical cognitive neuroscience.
Bruce Miller
BIO
Bruce L. Miller, MD, holds the A.W. and Mary Margaret Clausen Distinguished Professorship in Neurology at the University of California, San Francisco, directs the UCSF Memory and Aging Center and is a director of the Global Brain Health Institute. He is the principal investigator of the NIH-sponsored UCSF Alzheimer’s Disease Research Center and program project grant on frontotemporal dementia. In addition, he helps lead the Tau Consortium and The Bluefield Foundation, precision medicine collaborations focused on developing treatments for tauopathies and progranulin-mediated forms of frontotemporal dementia.
Miller is a behavioral neurologist who studies the underlying mechanisms of neurocognitive disorders and is a world-renowned expert in the diagnosis and management of dementia. Until recently, most cases of dementia were classified as Alzheimer’s disease with little awareness of the importance of non-Alzheimer dementias. Miller’s description of changes in behavior, language and emotion in the setting of aging have improved the separation of various neurodegenerative diseases from one another, in particular Alzheimer’s disease from frontotemporal dementia. To support people after diagnosis, Miller has pioneered groundbreaking changes in the provision of care coordination for patients with dementia and their caregivers. His ongoing work includes overseeing a healthy aging program and an artist in residence program, both of which emphasize positive aspects of aging.
Miller has been featured in Fortune Magazine, The New York Times, 60 Minutes and the PBS Newshour. He has authored more than 1000 publications and written The Human Frontal Lobes, The Behavioral Neurology of Dementia, Frontotemporal Dementia and Finding the Right Words, a book on Alzheimer’s disease from the perspective of a daughter written with Atlantic Fellow for Equity in Brain Health Cynthia Weinstein, PhD. He has received many awards including the Potamkin Award from the American Academy of Neurology, the Elliot Royer Award from the San Francisco Neurological community, the Robert A. Fishman Award and Lecture, and the UCSF Lifetime Achievement in Mentoring Award. He is an elected member of the National Academy of Medicine.
Miller’s extensive knowledge in clinical diagnosis, disease pathology, and brain-behavior relationships make him a widely sought-after teacher and mentor. He founded the Behavioral Neurology Fellowship at UCSF, oversees visits of more than 50 foreign scholars every year, and co-directs the Global Brain Health Institute, a training program for global leaders in brain health to reduce the scale and impact of dementia around the world. These international collaborations have fostered the development of new prevention and therapeutic approaches and have pushed researchers worldwide toward a more precise understanding of frontotemporal dementia and other neurodegenerative diseases.
Valcour Victor
BIO
Dr. Valcour is a Professor of Medicine with a shared appointment in the Division of Geriatric Medicine and the Department of Neurology. His work crosses disciplines to research and care for cognitive disorders in aging populations and to understand brain injury in the setting of HIV among all ages, including funded pediatric HIV studies. His clinical work involves consultations for patients with cognitive disorders at the UCSF Memory and Aging Center.
While much of Dr. Valcour’s research is completed at UCSF, he has a large international portfolio with many opportunities for junior investigators. Within Southeast Asia, he is Deputy Director of SEARCH/Thailand operating research in acute HIV (within days of infection), pediatric HIV, and markers of dementia in chronic HIV. In Africa, he has partnered with the US Military HIV Research Program to survey cognitive disorders among HIV-infected individuals in Nigeria, Uganda, Kenya, and Tanzania.
Dr. Valcour is broadly involved in mentoring individuals at all levels of training who are interested in clinical research related to cognitive disorders, particularly in association with HIV infection. He has extensive global health experience.
Dr. Valcour’s research interests have two major emphases. He is currently developing a research program that aims to understand optimal care strategies for elders who develop dementia. Nested within the Memory and Aging Center, the long-term goal of this program is to provide model care for elders with cognitive disorders.
Dr. Valcour is internationally recognized for research in cognitive disorders related to HIV. He currently operates 3 NIH R01 series grants within 3 novel cohorts: (1) a chronic HIV infected cohort followed since first initiation of cART; (2) an acute HIV cohort of individuals infected for less than one month at enrollment; (3) and a pediatric cohort in Thailand and Cambodia. He is the Deputy Director of SEARCH/Thailand
(www.SEARCHThailand.org). He also operates the UCSF HIV Over 60 Cohort focused on understanding cognitive disorders in the older HIV population living in the San Francisco Bay area. New research will survey of cognitive disorders in HIV for individuals living in Uganda, Kenya, Tanzania and Nigeria.
Dr. Valcour is actively engaged in mentoring individuals wishing to become independent clinical researchers. His research portfolio provides a broad array of local and international projects that can serve as resources for mentored projects. Dr. Valcour serves as an Executive Committee member of the AIDS Research Institute (ARI).
Shireen Javandel
BIO
Shireen coordinates the HIV research program at the Memory and Aging Center, including a number of domestic and international protocols focused on studying the impact of HIV infection on cognition. She also supports the Atlantic Fellows for Equity in Brain Health and faculty within the Global Brain Health Institute to facilitate research studies aiming to understand neurodegeneration and test strategies to reduce the global impact of dementia.
Shireen previously worked in education, coordinating work-place-based mentorships for underserved middle school students. She earned a bachelor’s degree in molecular and cell biology from UC Berkeley and a post-baccalaureate certificate in Interdepartmental Medical Sciences from Drexel University. She has worked at the Memory and Aging Center since 2014.
Jennifer Yokoyama
BIO
Jennifer Yokoyama obtained her doctorate degree in Pharmaceutical Sciences and Pharmacogenomics from UCSF in December 2010 with Dr. Steven Hamilton (Department of Psychiatry and Institute for Human Genetics). Her dissertation comprised work within the Canine Behavioral Genetics Project, utilizing purebred dogs as genetic models for studying neuropsychiatric disease. Utilizing community-based canine DNA samples, Dr. Yokoyama performed genome-wide surveys for genetic loci underlying the canine anxiety disorder noise phobia, as well as for loci underlying adult-onset deafness in border collies.
Dr. Yokoyama is currently an Associate Professor at the Memory and Aging Center, where she is beginning a research program in neurogenetics of aging. Specifically, she is interested in the effect genotype can have on brain physiology, behavior and cognition in healthy older adults, and how this is related to increased vulnerability to (or protection from) neurodegenerative processes during aging. She is also particularly interested in understanding these effects in diverse ethnic populations. Dr. Yokoyama’s long-term goal is to understand how variation across the entire genome confers risk for particular types of neurodegeneration for purposes of early treatment and therapeutic intervention.
In 2020, Dr. Yokoyama received the Alzheimer’s Association Excellence in Neuroscience Mentoring Award in recognition of her mentorship, advocacy, sponsorship and guidance of trainees in her laboratory. And in 2021, she received the Mary Oakley Foundation Professorship in Neurodegeneration.
Katherine Possin
BIO
Dr. Possin’s research program is focused on improving the detection, diagnosis and care for people with neurodegenerative disease. She has long-standing interests in understanding the cognitive impairments and their neural bases in neurodegenerative diseases including Alzheimer’s disease, Lewy body disease, Huntington’s disease, chronic traumatic encephalopathy and frontotemporal lobar degeneration. She is the project lead of TabCAT, a software platform for tablet-based cognitive testing frequently used in research studies and clinical services. The Brain Health Assessment is a 10-minute assessment on TabCAT designed for the detection of cognitive impairment in everyday clinical settings. She also the principal investigator of the Care Ecosystem, a telephone-based supportive care program for persons with dementia and their caregivers. Dr. Possin is a faculty member at the Global Brain Health Institute.
Kate Possin was awarded her PhD degree in clinical psychology from the University of California, San Diego. During her training at UCSD, she studied cognitive changes associated with Parkinson’s disease. She completed her internship in clinical neuropsychology at UC San Francisco in the departments of psychiatry and neurology and did her postdoctoral fellowship in the UCSF Department of Neurology. She currently holds the John Douglas French Alzheimer’s Foundation Endowed Professorship and is an associate professor in residence in the Department of Neurology.
Dr. Possin is accepting applications for a postdoctoral fellowship in neuropsychology and a postdoctoral fellowship in dementia healthcare innovation.
Natália Vieira
BIO
Natália Vieira is an international student from Brazil in her first year as a master’s student in the cell and molecular biology program at San Francisco State University. Her project is a partnership between the Health & Equity Research Lab at SF State and the Yokoyama Lab at UCSF.
She is currently studying Alzheimer’s disease (AD) in an admixed cohort, trying to predict the age of onset of AD. In addition to this research project, she is a member of the ReDLat team at UCSF. She is responsible for reviewing sample shipment manifests and managing shipping authorizations.
Nick Cochran
BIO
Dr. Nick Cochran obtained his undergraduate degree in 2010 from Auburn University where he conducted research with Douglas Martin, his PhD in neuroscience from UAB in 2015 where we trained with Erik Roberson, and completed a postdoctoral fellowship in 2021 with Richard Myers at HudsonAlpha before continuing on as a Faculty Investigator at HudsonAlpha. Throughout his career, Nick has focused on contributing to research on Alzheimer’s disease and other neurodegenerative diseases. Current Cochran lab projects focus on: (1) right-sizing both genetic association studies in underrepresented populations and applying functional genomics approaches in a manner relevant to underrepresented populations to properly capture how genetic diversity both at the individual and population levels could influence the effects of genetic variation, (2) obtaining a detailed understanding of the regulation of neurodegeneration-associated genes to propose new therapeutic approaches, and (3) working towards a higher level of evidence for non-coding variation (with a focus on rare non-coding variation) to provide a toolbox to understand disease risk.
Ken Kosik
BIO
Kenneth S. Kosik, M.A. M.D. served as professor at the Harvard Medical School from 1996 until 2004 when he became the Harriman Professor and Co-Director of the Neuroscience Research Institute at UCSB. His awards include Whitaker Health Sciences Award (MIT), Milton Foundation Award (Harvard Medical School), Moore Award (American Association of Neuropathologists), Metropolitan Life Award, Derek Denny-Brown Award (American Neurological Association), Zenith and Temple Awards (Alzheimer’s Association), Ranwell Caputo Medal (Argentine Society of Neurochemistry), NASA Group Achievement Award to Neurolab Team, the Premio Aventis (Academia Nacional de Medicina, Colombia), Potamkin Prize for Research in Pick’s, Alzheimer’s and Related Diseases (2021), a fellow of the American Association for the Advancement of Science (AAAS) and Santa Barbara Innovation Star Award.
He co-authored Outsmarting Alzheimer’s Disease and The Alzheimer’s Solution: How Today’s Care is Failing Millions and How We Can Do Better. His work on Tau pathology and his work in Colombia with the largest family in the world afflicted with familial Alzheimer’s has appeared in the New York Times, Wall Street Journal, New Yorker, BBC, CNN, PBS and CBS 60 Minutes. His 2016 University of California Santa Barbara commencement address archived at the Graduation Wisdom Best Commencement Speeches web site is here:
Nilton Custodio
BIO
Dr. Nilton Custodio is a neurologist interested in global approaches to neurodegenerative diseases with special interest in vulnerable (low education) and native (Aymara and Quechua) populations. He is medical director of the Peruvian Institute of Neurosciences. He trained as a clinical neurologist, obtained a Master’s degree in Medicine and a PhD in Neurosciences from the Universidad Nacional Mayor de San Marcos. He is a Fellow of the American Academy of Neurology (FAAN) since 2017. He has been president of the Peruvian Society of Neurology.
He has contributed to more than 100 scientific publications in high impact journals and is associate editor of different journals. In the last 5 years, he has obtained research funding from different international associations such as Alzheimer’s Association, National Institute of Health/National Institute of Aging, and MRC (UK).
He is a founding member of the Latin American and Caribbean Consortium on Dementia (LAC-CD) and of important regional initiatives, such as the Multi-partner Consortium to expand dementia research in Latin America (ReDLat), Genetics in Alzheimer’s Peruvian Population (GAPP), Iniciativa Latinoamericana de intervención para prevenir el deterioro cognitivo (LatAm fingers) and Innovations using mHealth for People with Dementia and Co-Morbidity and their Carers (IMPACT).
Elisa Resende
BIO
Elisa Resende received her medical school training from the Universidade Federal de Minas Gerais, Brazil. She received her PhD in Neuroscience at the same University. Elisa did her residency in Neurology at the Hospital das Clínicas-UFMG/EBSERH. After one year of fellowship in Behavioral Neurology and Movement Disorders, she joined the hospital staff as assistant physician. She is an Atlantic Fellow for Equity in Brain Health and teaches behavioral neurology at Faculdade de Medicina de Ciências Médicas de Minas Gerais
Leonel Takada
BIO
Dr. Takada is a behavioral neurologist, trained at University of Sao Paulo in Brazil and at UCSF Memory and Aging Center, USA (as a visiting scholar). He obtained his PhD in 2015, in which he studied monogenic forms of FTD in Brazil. His main research interests are monogenic forms of early-onset dementia (particularly AD and FTD) and the development of apps to improve quality of life in patients with mild cognitive impairment and dementia.
Maira Okada
BIO
Graduated in Psychology from Universidade Presbiteriana Mackenzie, Master and PhD in Sciences from the Department of Neurology at HCFMUSP, specialist in Neuropsychology, Global Atlantic Fellow for Equity in Brain Heath at GBHI. She is currently a researcher at the Cognitive and Behavior Neurology Group (GNCC) at HCFMUSP and at the Cognitive Disorders Reference Center (CEREDIC) at HCFMUSP, Neuropsychologist at Hospital Santa Marcelina, member of ReD-Lat project and associated editor of Dementia & Neuropsychologia Journal.
https://lattes.cnpq.br/6934310043474462
ORCID ID: 0000-0001-8423-9876
National Institute of Medical Sciences and Nutrition Salvador Zubirán (Mexico)
Jose Alberto Avila-Funes
BIO
Dr. Avila-Funes (MD, PhD) is an undergraduate and graduate professor of geriatrics and his main line of research is frailty and cognitive decline. He is a researcher associate of the ACTIVE team (U1219) of the INSERM (France).
He is a member of the national system of researchers and of the National Academy of Medicine of Mexico as well as the Latin American Academy of Medicine for the Older Adults.
He is currently the leader of the geriatric service at the National Institute of Medical Sciences and Nutrition Salvador Zubirán in Mexico City.
Stefanie Piña Escudero
BIO
Stefanie Piña Escudero is an graduated as an MD from the National Autonomous University of Mexico. She became a specialist in Internal Medicine at the Nuevo Sanatorio Durango and in Geriatrics at the the National Institute of Medical Sciences and Nutrition Salvador Zubirán. She is an Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute at the University of California, San Francisco.
She is currently pursuing a PhD in Pharmaceutical Sciences and Pharmacogenomics at the University of California, San Francisco. Co-founder of the MUGER group (Women in Geriatrics in Mexico). She currently works as Protocol Director of the RedLat Project.
Francisco Javier Lopera Restrepo
BIO
Dr. Lopera is a physician, neurologist and professor at the University of Antioquia with a subspecialty in neuropediatrics from the Catholic University of Louvain. As a medical resident in the 1980’s, he was led by curiosity to spend many weekends visiting small towns to speak to patients suffering from dementia without realizing that he would eventually map the world’s largest population with early onset familial Alzheimer’s linked to a mutation in the presenilin 1 gene. Dr. Lopera’s friendly, charismatic personality earned him the trust of patients and families, an accomplishment that has been as important as the science behind this story.
As Chief of the Neuroscience Group of Antioquia (GNA), he and his lab investigate neurodegenerative diseases and treat patients with Alzheimer’s Disease, CADASIL, Parkinson’s, Huntington’s, Frontotemporal Dementia and other forms of dementia. He is the principal investigator of the first preventive clinical trial in Colombia for Alzheimer’s disease called API Colombia. His work has been instrumental in gaining the recognition and funding for the creation of an International Center for Clinical Trials in Medellin which will be inaugurated in 2022. He has received numerous awards, including the Alejandro Ángel Escobar Award for exact, physical and natural sciences in 1997 and 2013; and the Bengt Winblad Lifetime Achievement Award by the Alzheimer’s Association in 2020.
Diana Matallana
BIO
Psychologist with graduate studies in Experimental Neuropsychology. Professor at the Pontificia Universidad Javeriana, Faculty of Medicine, in Bogotá-Colombia since 1986. Currently Full Professor since 2008. Main experience field is as a clinical Neuropsychologist and researcher focused on studies directed to understand cognition in normal aging driving population studies that include mental health social cognition domains. Along with the later, sequelae of neurological, psychiatric and neurodegenerative diseases such as early onset Alzheimer’s disease (AD) and non-AD dementias, mostly Frontotemporal dementia FTD, are her main areas of research and clinical practice. Since 1992, along with her colleagues, created the Memory and Cognition Clinic Center (MCC-Intellectus) at the University San Ignacio´s Hospital of the Javeriana University. Today at that center more than 45 new subjects, a week, go under an interdisciplinary consensus-based diagnosis and management board. Since 2008, until today, she has had the opportunity to investigate early onset FTD dementia trough University, and two Fogarty Grants, have allowed her to lead the early identification of interesting genetics associated with FTD in Colombia. It is intended that one of the main contributions to the Red Lat project is the way in which patients and families are studied throughout the Colombian territory.
Agustin M. Ibañez
BIO
Agustin Ibanez is an Argentinean neuroscientist interested in global approaches to dementia and social, cognitive, and affective neuroscience. He is full professor and Director of the Latin American Brain Health Institute (BrainLat) at Universidad Adolfo Ibáñez (UAI, Chile), Associate Research Professor at GBHI-Trinity College Dublin, and Team Leader of Predictive Brain Health Modelling Group, Trinity College Dublin. Also, he is a Senior Atlantic Fellow at GBHI-UCSF and senior researcher at UdeSA. Agustin holds a track record with +300 publications, including top-ten journals (e.g., Lancet Neurology, World Psychiatry, Nature Reviews Neurology, Nature Human Behavior, Trends in Cognitive Sciences, Trends in Neuroscience, JAMA Neurology, Alzheimer’s & Dementia, Neuron, Brain). He has received funding from the NIH, Alzheimer’s Association, Tau Consortium, GBHI, Takeda, the Inter-American Development Bank(IDB), ANID (Chile), COLCIENCIAS (Colombia), DAAD (Germany), MRC (United Kingdom), and CONICET (Argentina). He is the founder of the critical regional initiatives, such as the Multi-partner consortium to expand dementia research in Latin America (ReDLat) and the Latin American and Caribbean Consortium on Dementia (LAC-CD). His work has been highlighted in the BBC, Nature, Nature News, Discovery Channel, Popular Science, Daily Mail, Newsweek, Le Monde, and Oxford University Press, among others.
Adolfo M. Garcia
BIO
Dr. Adolfo García specializes in language neurosciences. He is Director of the Center for Cognitive Neurosciences of the University of San Andrés, Senior Atlantic Fellow of the GBHI (UCSF), Researcher of the USACH and CONICET, honorary member of the Center for Cognitive Neuroscience of the ULL (Spain), and High Level Talent designated by the Ministry of Science of China. He is also President of the TREC Network.
Adolfo has received funding from institutions in the US (GBHI, Alzheimer’s Association), Chile (ANID, BrainLat), Colombia (COLCIENCIAS), the European Union (Network of European Institutes for Advanced Study), among others. Since 2023, he has been co-leading an NIH R01 project to detect linguistic markers of dementia, within the framework of ReDLat. He is also the creator of Include, an international network of cross-linguistic studies in brain health; and the Toolkit to Examine Lifelike Language (TELL), a web application for language assessments.
In addition, he has published more than 12 books, 30 chapters, and 180 articles in leading international journals. He has also made more than 250 presentations at academic events and multiple scientific outreach activities. His work has been awarded by internationally recognized institutions. You can find more information about Adolfo on his website.
Martin Bruno
BIO
Martin A. Bruno: PhD (McGill University, Montreal, Canada), Researcher at CONICET-Argentina (National Scientific and Technical Research Council), Professor of Medicine and Coordinator of the Doctorate in Biomedical Sciences (Catholic University of Cuyo, San Juan, Argentina), Director of the Institute of Biomedical Sciences (ICBM), Faculty of Biomedical Sciences (Catholic University of Cuyo, San Juan, Argentina) Principal Investigator (PI) of the Provincial Plan for the Prevention and Detection of Dementia (COFECyT, San Juan 2022-2023), Principal Investigator of Clinic.
Luis Ignacio Brusco
BIO
Dean of the School of Medicine-UBA. He is Doctor of Medicine (University of Buenos Aires-UBA) and Doctor of Philosophy. Head of the Department of Psychiatry and Mental Health of the Faculty of Medicine, UBA.
Neurologist and Psychiatrist, Argentine researcher and educator specialized in cognitive neuroscience and philosophy of mind. Dean of the Faculty of Medical Sciences of the University of Buenos Aires. Director of the Alzheimer Center and Cognitive Functions UBA. He is a researcher at CONICET and directs the Alzheimer Argentina Association. Author of numerous books and multiple articles in high impact journals.
Maria Eugenia Godoy
BIO
María Eugenia Godoy has a degree in Government and International Relations from the Universidad Argentina de la Empresa (UADE). After that, she obtained a Master Degree in Institutional Communication Management at the Universidad de Ciencias Empresariales (UCES). Then, she extended her training in Project Management at the Universidad tecnológica Nacional (UTN).
Currently, she is Program Manager of the NIH/NIR R01: “Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)”. She is also in charge of managing international grants and local grants. She has strong experience in international applications.
Previously, she worked as coordinator of Bilateral Cooperation at the National Directorate for Institutional Integration and Cooperation of the Ministry of Science, Technology and Productive Innovation of Argentina.
She has participated in international negotiations such as: Annual LAC NCPs meeting ALCUANET (Bridgetown, Barbados), High-Level Meeting (South Africa), Seminar on Fusion of Business Culture between China and Argentina (Beijing-Shanghái-Qingdao, China), Russian-Argentine Joint Commission on Economic-Commercial and Scientific- Technical Cooperation (Moscow, Russia).
Marcelo Maito
BIO
Marcelo Adrián Maito is a graduate of Political Science from the University of Buenos Aires. Afterward, he attended postgraduate studies in Research Methodology in Social Sciences at Universidad Nacional Tres de Febrero (UNTREF) and obtained a Master’s degree in n Data Mining and Knowledge Management at Austral University (UA).
Currently, he is the Data Manager of the NIH/NIR R01: “Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)” and Online Researcher of the “Global Datos Brain Health Latam” project at the School of Psychology of the Universidad Adolfo Ibañez.
He has extensive experience in the health sector, working for more than ten years at the National Administration of Medicines, Food and Medical Technology (ANMAT).
He fulfilled functions of representation and negotiation of technical regulations within the framework of MERCOSUR, in bilateral cooperation projects, and managing regional cooperation projects. Subsequently, he carried out training and research tasks in the Coordination of Training and Scientific-Sanitary Research and was in charge of the “Strategic Data Analytical Innovation Program”.
Agustin M. Ibañez
BIO
Agustin Ibanez is an Argentinean neuroscientist interested in global approaches to dementia and social, cognitive, and affective neuroscience. He is full professor and Director of the Latin American Brain Health Institute (BrainLat) at Universidad Adolfo Ibáñez (UAI, Chile), Associate Research Professor at GBHI-Trinity College Dublin, and Team Leader of Predictive Brain Health Modelling Group, Trinity College Dublin. Also, he is a Senior Atlantic Fellow at GBHI-UCSF and senior researcher at UdeSA. Agustin holds a track record with +300 publications, including top-ten journals (e.g., Lancet Neurology, World Psychiatry, Nature Reviews Neurology, Nature Human Behavior, Trends in Cognitive Sciences, Trends in Neuroscience, JAMA Neurology, Alzheimer’s & Dementia, Neuron, Brain). He has received funding from the NIH, Alzheimer’s Association, Tau Consortium, GBHI, Takeda, the Inter-American Development Bank(IDB), ANID (Chile), COLCIENCIAS (Colombia), DAAD (Germany), MRC (United Kingdom), and CONICET (Argentina). He is the founder of the critical regional initiatives, such as the Multi-partner consortium to expand dementia research in Latin America (ReDLat) and the Latin American and Caribbean Consortium on Dementia (LAC-CD). His work has been highlighted in the BBC, Nature, Nature News, Discovery Channel, Popular Science, Daily Mail, Newsweek, Le Monde, and Oxford University Press, among others.
Claudia Duran-Aniotz
BIO
Claudia Duran-Aniotz is a neuroscientist fully dedicated to understand neurodegenerative disorders with special emphasis in Alzheimer’s disease.
Since, early diagnosis and biomarkers research are areas poorly developed in Latin America countries, she has focused her work to Alzheimer’s disease and dementia affecting this particular population contributing to diminish the major economical and social costs associated with brain health disorders. Her research and academic interests are aligned to provide a useful platform to generate new knowledge and link basic and clinical research, promoting high translational discoveries and clinical collaborations. Her projects encourage the consolidation of a research group to study the neuropathological, clinical and translational research in Alzheimer’s disease. Currently, Dr. Duran-Aniotz is assistant professor and co-Director of Latin American Brain Health Institute (BrainLat) at Universidad Adolfo Ibáñez (UAI) and she is also actively involved to regional initiatives, including the Multi-partner consortium to expand dementia research in Latin America (ReDLat) as member of the specimen handling group and the Latin American and Caribbean Consortium on Dementia (LAC-CD) as a member of the Biomarkers framework.
Rodrigo Ortega
BIO
Rodrigo Ortega is Psychologist (Universidad Central de Chile), Master in Neurobiology and Ph.D. in Psychology (Universidad de Chile). With extensive professional experience in interdisciplinary research in Neuroscience. He has worked in large public and private funded projects in Cognitive Neuroscience, as a researcher and in other administrative positions. He has participated in the setup of several neurophysiological laboratories and has advanced skills in electrophysiological and eye-tracking data collection and analysis. Since July 2021, he is Program Manager at BrainLat.
Maria Eugenia Godoy
BIO
María Eugenia Godoy has a degree in Government and International Relations (UADE). She has a Master’s Degree in Institutional Communication Management (UCES) and a specialization in Project Management from the National Technological University.
She has also completed a postgraduate course in Scientific Diplomacy applied to neurosciences (UNESCO) and has completed an Intensive Postgraduate Course on Global Brain Health at the University of Chile.
She is currently project manager of the Multi-Partner Consortium to expand Dementia Research in Latin America (ReDLat) and is in charge of the integral management of international governmental, philanthropic and industrial projects. She also serves as an international consultant at the Latin American Institute of Brain Health (BrainLat), Universidad Adolfo Ibañez (Chile).
She has been working for more than 15 years in the field of Science, Technology and Innovation, participating in the development of partnerships and projects on an international scale. He has extensive experience in the management and management of consortia projects as well as in the participation in international negotiations.
Andrea Slachevsky
BIO
Andrea Slachevsky, neurologist, PhD in neurosciences Université Pierre et Marie Curie, Paris VI, France. Associate Professor, Faculty of Medicine, University of Chile. Principal Investigator of the Center for Geroscience, Mental Health and Metabolism (GERO). Coordinator Memory Unit, Memory and Neuropsychiatry Center (CMYN), Neurology Service, Hospital del Salvador, Faculty of Medicine, University of Chile Neurologist, Clínica Alemana Vice President and creator of Coprad (Corporación Profesional de Alzheimer y Otras Demencias), a non-governmental, non-profit organization dedicated to raising awareness about Alzheimer’s disease and other dementias.
Member of the board of directors of the Global Brain Health Institute. She participated in the development of the National Dementia Plan in Chile and in the creation of one of the memory units implemented in the context of Chile’s national dementia plan.
Her line of research focuses on neuropsychological and functionality in aging and neurocognitive disorders. She has published more than 100 articles and more than 20 book chapters. She has written or edited four books, Alzheimer’s disease and other dementias. Manual for relatives and caregivers, Neuropsychology. Neural basis of mental processes, , Tratado de Neuropsicología, Cerebro Cotidiano and Manual de buenas prácticas para el diagnóstico de demencias
Maria Isabel Behrens
BIO
María Isabel Behrens, MD PhD, Full Professor at the University of Chile, neurologist and researcher dedicated to the study of the molecular mechanisms of dementia, especially the inverse relationship between Alzheimer’s disease and cancer. She was director of the Department of Neurology and Neurosurgery (2017-2019) Hospital Clínico Universidad de Chile, and is currently director of the Center for Advanced Clinical Research (CICA)-Hospital Clínico Universidad de Chile. She is Principal Investigator of a Regular FONDECYT project and a FONDEF, among other collaborative works in progress. He leads a pre-clinical study to explore a new therapy for Alzheimer’s disease. She has directed 9 projects as principal investigator, and 14 as co-investigator or associate, with 92 scientific publications. He does translational research and teaches both in the neurology clinic and in the direction of master’s and doctoral theses. Member of committees of various doctorates from the University of Chile. Awarded the “2019 Medical Research Award” and incorporated as a corresponding member of the Chilean Academy of Medicine. He constantly gives lectures on Alzheimer’s and other dementias in postgraduate courses at different universities and in the media. Dr. Behrens has a network of national and international collaborators.