The project

This project fosters a Consortium with support from multiple partners whose goal is to expand dementia research in Latin America and the Caribbean (LAC). The Consortium aims to combine genomic, neuroimaging and behavioral (clinical, cognitive, socioeconomic) data to improve dementia characterization and identify novel inroads to treat neurodegeneration in diverse populations. This 5-year project constitutes an unprecedented opportunity to foster regional synergy and multidisciplinary research to promote harmonization of global strategies to treat and, ultimately, prevent dementia in diverse and underserved populations around the world. We will develop an innovative, harmonized, and cross-regional approach on two of their most prevalent neurodegenerative disorders: Alzheimer’s disease (AD) and frontotemporal dementia (FTD).

We combine R01 funding (“US-South American initiative for genetic-neural-behavioral interactions in human neurodegenerative research”, R01 AG057234) with additional support. The R01 project provides a basic platform anchored in Argentina, Brazil, Colombia, and Peru, that is supplemented with clinical research expertise from the University of California, San Francisco (UCSF) Memory and Aging Center, genomics expertise from the University of California, Santa Barbara, and bioinformatics infrastructure and expertise from HudsonAlpha. Then other countries (Mexico, Chile and others from the LAC-CD consortium) joined the project with the support of the Alzheimer’s Association and the Rainwater Charitable Foundation. Satellite projects are now expanding the initial ReDLat initiative to include family assessments (Alector, Bluefield), EEG recordings (Takeda), natural speech analysys (NIH/NIA) and learning experiences (BrainLat, GBHI).


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