Authors: Buée L, Wildsmith KR, Alladi S, Bertucci T, Boche D, Bowles KR, Boxer A, Brummet J, DeVos SL, Diaz K, Dreyer AJ, Duff K, Duran-Aniotz C, Durrant CS, Farrell K, Fontana IC, Franzmeier N, Frost B, Horie K, Kaňovský P, Kao AW, Mahinrad S, Malpetti M, Morris HR, Palleis C, Petrucelli L, Rexach J, Reyderman L, Rommel A, Rowe JB, Sanabria Bohórquez SM, Sato C, Schöll M, Schneider A, de Silva R, Snyder HM, VandeVrede L, Varga AW, Vogel JW, Yeh FL, Yoo AS, Carrillo MC.

Abstract: The Tau Global Conference 2025, hosted by the Alzheimer’s Association, CurePSP, and the Rainwater Charitable Foundation, convened international experts from academia, industry, government, and philanthropy to explore advances and challenges in tauopathy research. The meeting highlighted progress across tau biology, including emerging models of tau regulation, degradation, and propagation; advances in biomarker development for the diagnosis and staging of tauopathies; and evolving therapeutic strategies targeting diverse aspects of tau pathophysiology. Discussions also emphasized the importance of cross-sector collaboration, and global initiatives to address disparities in tau research. This report synthesizes key insights from the conference and underscores the critical role of interdisciplinary, biomarker-driven, and globally inclusive approaches in accelerating the translation of tau research into effective clinical applications.