Authors: Udeh-Momoh, C., Maina, R., Anazodo, U., Akinyemi, R., Atwoli, L., Baker, L., Bassil, D., Blackmon, K., Bosire, E., Chemutai, G., Crivelli, L., Eze, L.U., Ibanez, A., Kafetsouli, D., Karikari, T.K., Khakali, L., Kumar, M., Lengyel, I., de Jager Loots, C.A., Mangialasche, F., Mbugua, S., Merali, Z., Mielke, M., Mostert, C., Muthoni, E., Nesic-Taylor, O., Ngugi, A., Nguku, S., Ogunniyi, A., Ogunyemi, A., Okonkwo, O.C., Okubadejo, N., Perneczky, R., Peto, T., Riang’a, R.M., Saleh, M., Sayed, S., Shah, J., Shah, S., Solomon, A., Thesen, T., Trepel, D., Ucheagwu, V., Valcour, V., Waa, S., Watermeyer, T., Yokoyama, J., Zetterberg, H., Kivipelto, M & Africa-FINGERS Study Team.

Abstract: Dementia prevention in Africa is critically underexplored, despite the continent’s high prevalence of modifiable risk factors. With a predominantly young and middle-aged population, Africa presents a prime opportunity to implement evidence-based strategies that could significantly reduce future dementia cases and mitigate its economic impact. The multinational Africa-FINGERS program offers an innovative solution, pioneering culturally sensitive, multidomain interventions tailored to the unique challenges of the region.  Leveraging insights from landmark global studies such as Worldwide-FINGERS and Alzheimer’s Disease Neuroimaging Initiative, the program employs a multideterminant precision prevention framework, grounded in community based systems dynamics. Africa-FINGERS further integrates cutting-edge state-of-the-art multimodal biomarker evaluations tailored to regional contexts, with the goal of advancing brain health and establishing a global standard for dementia prevention. This groundbreaking initiative highlights the potential for scalableand sustainable interventions, thus is poised to transform dementia risk reduction efforts across the continent.